Prenatal Activation of Microglia Induces Delayed Impairment of Glutamatergic Synaptic Function

@article{Roumier2008PrenatalAO,
  title={Prenatal Activation of Microglia Induces Delayed Impairment of Glutamatergic Synaptic Function},
  author={Anne Roumier and Olivier Pascual and Catherine B{\'e}chade and Shirley Wakselman and Jean-Christophe Poncer and El{\'e}onore R{\'e}al and Antoine Triller and Alain Bessis},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={115 - 118}
}
BACKGROUND Epidemiological studies have linked maternal infection during pregnancy to later development of neuropsychiatric disorders in the offspring. In mice, experimental inflammation during embryonic development impairs behavioral and cognitive performances in adulthood. Synaptic dysfunctions may be at the origin of cognitive impairments, however the link between prenatal inflammation and synaptic defects remains to be established. METHODOLOGY/PRINCIPAL FINDINGS In this study, we show… CONTINUE READING
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