Premutilin Synthase: Ring Rearrangement by a Class II Diterpene Cyclase.

Abstract

Biosynthesis of the complex diterpenoid antibiotic pleuromutilin relies on a bifunctional (di)terpene synthase, and here site-directed mutagenesis was used to knockout either of the two active sites. This enabled characterization of the novel ring contracted intermediate produced by the initiating class II diterpene cyclase active site. Quantum chemical… (More)
DOI: 10.1021/acs.orglett.8b00121

Topics

  • Presentations referencing similar topics