Premorbid characterization in schizophrenia: the Pittsburgh High Risk Study.

  title={Premorbid characterization in schizophrenia: the Pittsburgh High Risk Study.},
  author={Matcheri S. Keshavan and Vaibhav A. Diwadkar and Debra M. Montrose and Jeff Stanley and Jay W. Pettegrew},
  journal={World psychiatry : official journal of the World Psychiatric Association},
  volume={3 3},
Prospective studies of young relatives at risk for schizophrenia can shed light on the possible premorbid precursors of the disease. Ongoing studies in Pittsburgh suggest that young non-psychotic high risk relatives have neurobehavioral, brain structural, physiological, and neurochemical deficits that may date back to childhood or earlier. We summarize these data, review the relevant literature in this emerging field, and provide some new data suggesting alterations in sleep architecture in… CONTINUE READING

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