Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer's disease.

@article{Mori1997PremorbidBS,
  title={Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer's disease.},
  author={Etsuro Mori and Nobutsugu Hirono and Hirohumi Yamashita and Toru Imamura and Yoshitaka Ikejiri and Manabu Ikeda and Hajime Kitagaki and Tatsuo Shimomura and Yukihiro Yoneda},
  journal={The American journal of psychiatry},
  year={1997},
  volume={154 1},
  pages={18-24}
}
OBJECTIVE Both the magnitude of brain atrophy and premorbid brain size determine the volume of the brain affected by Alzheimer's disease. To examine the possibility that premorbid brain volume is a determinant of cognitive reserve in patients with Alzheimer's disease, the relation between diffuse brain atrophy and cognitive decline and the impact of premorbid brain size on cognitive decline were studied in patients with Alzheimer's disease. METHOD By measuring whole brain volume and… CONTINUE READING

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