Premorbid Intellectual Functioning, Education, and Brain Size in Traumatic Brain Injury: An Investigation of the Cognitive Reserve Hypothesis

@article{Kesler2003PremorbidIF,
  title={Premorbid Intellectual Functioning, Education, and Brain Size in Traumatic Brain Injury: An Investigation of the Cognitive Reserve Hypothesis},
  author={Shelli R. Kesler and Heather Adams and Christine M. Blasey and Erin D. Bigler},
  journal={Applied Neuropsychology},
  year={2003},
  volume={10},
  pages={153 - 162}
}
Cognitive reserve theories have been postulated in an attempt to explain individual differences in functional outcome following cerebral insult or disease. These theories suggest that higher education and psychometric intelligence may preserve functional capacity regardless of injury or disease severity. This study investigated cognitive reserve in 25 participants with traumatic brain injury (TBI) using high-resolution magnetic resonance imaging (MRI) analyses. We examined the relationships… 
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A clinical cutoff below which CR is no longer protective, together with a possible neuropathology ceiling effect, may be instructive for prognostication and clinical decision-making in cognitive rehabilitation.
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Findings suggest that the protective effects of CR are temporally delimited, potentially contending with declines in brain reserve, and traditional outcome determinants should be considered in the context of injury chronicity.
Neuropsychological Functioning in a National Cohort of Severe Traumatic Brain Injury: Demographic and Acute Injury–Related Predictors
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Findings highlight cognitive consequences of severe TBI, with nearly two-thirds of patients showing cognitive impairments in at least 1 of 3 cognitive domains and only PTA duration was related to cognitive functioning.
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