Premitotic Assembly of Human CENPs -T and -W Switches Centromeric Chromatin to a Mitotic State

@inproceedings{Prendergast2011PremitoticAO,
  title={Premitotic Assembly of Human CENPs -T and -W Switches Centromeric Chromatin to a Mitotic State},
  author={L. J. Prendergast and Chelly van Vuuren and Agnieszka Kaczmarczyk and Volker Doering and Daniela Hellwig and Nadine Quinn and Christian Hoischen and Stephan Diekmann and Kevin F. Sullivan},
  booktitle={PLoS biology},
  year={2011}
}
Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that their identity in most organisms is determined not by the DNA sequences they are associated with, but through specific chromatin composition and context. The core nucleosomal protein CENP-A/cenH3 plays a primary role in centromere determination in all species and directs… CONTINUE READING