Premenstrual Syndrome: Evidence-based Evaluation and Treatment

  title={Premenstrual Syndrome: Evidence-based Evaluation and Treatment},
  author={Sarah M. Appleton},
  journal={Clinical Obstetrics and Gynecology},
  • S. M. Appleton
  • Published 2018
  • Psychology, Medicine
  • Clinical Obstetrics and Gynecology
Premenstrual dysphoric disorder (PMDD) is defined by both physical and psychiatric symptoms that impact a woman significantly during the luteal phase of her menstrual cycle. Diagnostic criteria for PMDD were firmly established in the Diagnostic and Statistical Manual of Mental Disorders V in 2013, but many patients fall short of the diagnosis while still appreciably affected by severe premenstrual symptoms. More recent and robust investigations have evaluated the efficacy of treatment ranging… 
Comorbid Premenstrual Dysphoric Disorder in Women with Bipolar Disorder: Management Challenges
The management of comorbid PMDD/BD needs as a first step to stabilize the bipolar symptoms by means of optimal dosages of mood stabilizers, and in euthymic BD patients, the PMDD symptoms could be treated with estroprogestins.
Premenstrual syndrome and cortisol
Overall, PMS/PMDD impairs the quality of life, thus the more the authors understand about its pathogeny, the easier it gets to control it.
Insomnia, Inattention and Fatigue Symptoms of Women with Premenstrual Dysphoric Disorder
These symptoms are correlated with PMDD symptoms severity and functional impairment, and as such, they should be evaluated, and interventions should be employed in the late luteal phase of women with PM DD.
Evaluation of the frequency of premenstrual syndrome manifestations in the population of generative women
Women of reproductive age are highly exposed to premenstrual syndrome, all the symptoms of this syndrome affect the quality of life, work ability and family relations, and daily functioning.
Internet-based cognitive-behavioral therapy for premenstrual syndrome: a randomized controlled trial
The ICBT could reduce the symptom severity of women suffering from PMS while improving their perimenstrual quality of life, however, it had no significant effect on the late follicularquality of life.
Internet-Based Cognitive-Behavioural Intervention for Women with Premenstrual Dysphoric Disorder: A Randomized Controlled Trial
The iCBT was highly effective in reducing the burden of PMDD, and it appears to be particularly important to address coping styles and stress management in the treatment.
Is Premenstrual Syndrome Associated with Inflammation, Oxidative Stress and Antioxidant Status? A Systematic Review of Case–Control and Cross-Sectional Studies
Limited evidence indicates increased levels of inflammatory parameters and suggests decreased antioxidant status in PMS women and to acknowledge the role of inflammation, oxidative stress, and antioxidants status in the pathophysiology of PMS, further research with case–control design and large study groups is needed.
Emotion-focused group therapy among women with premenstrual dysphoric disorder: A randomized clinical trial
Investigating the effectiveness of emotion-focused group therapy (EFGT) in pain perception, self-compassion, sexual function, and couple burnout in women with PMDD found it seems that EFGT could be effective in womenwith PMDD.
NDT_A_202881 415..426
Gianna Sepede 1 Marcella Brunetti Massimo Di Giannantonio 1,2 1Department of Neuroscience, Imaging, and Clinical Sciences, University “G. d’Annunzio”, Chieti, Italy; 2Department of Mental Health


Exercise and premenstrual symptomatology: a comprehensive review.
  • A. Daley
  • Medicine, Psychology
    Journal of women's health
  • 2009
To make any evidence-based policy recommendations regarding the effectiveness of exercise, more high-quality research is required.
Efficacy of Depot Leuprolide in Premenstrual Syndrome: Effect of Symptom Severity and Type in a Controlled Trial
The differential response to leuprolide suggests that it may possess diagnostic value in determining distinct subtypes of PMS, and women should be evaluated for depression severity before receiving a GnRH agonist.
Selective serotonin reuptake inhibitors for premenstrual syndrome.
SSRIs were effective for symptom relief whether taken only in the luteal phase or continuously, with no clear evidence of a difference in effectiveness between these modes of administration.
The premenstrual symptoms screening tool (PSST) for clinicians
The PSST applies a necessary degree of measure of severity and impact of premenstrual symptoms, establishes quickly if women qualify for PMDD, and is less time consuming and more practical than two cycles of prospective charting.
Intercountry Assessment of the Impact of Severe Premenstrual Disorders on Work and Daily Activities
Women suffering from moderate-to-severe PMS/PMDD had increased work absenteeism and work productivity impairment due to premenstrual symptoms relative to those with mild PMS /no perceived symptoms.
Fluoxetine versus Vitex agnus castus extract in the treatment of premenstrual dysphoric disorder
This preliminary study suggests that patients with PMDD respond well to treatment with both fluoxetine and AC, however, fluoxettine was more effective for psychological symptoms while the extract diminished the physical symptoms.
Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study
Dry extract of agnus castus fruit is an effective and well tolerated treatment for the relief of symptoms of the premenstrual syndrome and indicates superiority of active treatment in each of the three global impression items.