Premature vascular damage in systemic lupus erythematosus: an imbalance of damage and repair?

@article{Kaplan2009PrematureVD,
  title={Premature vascular damage in systemic lupus erythematosus: an imbalance of damage and repair?},
  author={Mariana J Kaplan},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2009},
  volume={154 2},
  pages={61-9}
}
Systemic lupus erythematosus (SLE) is associated with an increase in the risk of premature cardiovascular complications caused by accelerated atherosclerosis, which significantly contributes to morbidity and mortality. Standard Framingham risk factors seem to be less important predictors of cardiovascular events than the presence of active SLE, and the immune dysregulation characteristic of lupus seems to play a dominant role in atherogenesis. Although both SLE-specific and nonspecific… CONTINUE READING