Premature translation termination mutations are efficiently suppressed in a highly conserved region of yeast Ste6p, a member of the ATP-binding cassette (ABC) transporter family.

@article{Fearon1994PrematureTT,
  title={Premature translation termination mutations are efficiently suppressed in a highly conserved region of yeast Ste6p, a member of the ATP-binding cassette (ABC) transporter family.},
  author={K Fearon and V McClendon and B Bonetti and David M. Bedwell},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 27},
  pages={17802-8}
}
The requirements for efficient translation termination are incompletely understood. Since the local context surrounding stop codons can influence the efficiency of translation termination, premature termination codons introduced by random mutation may not always terminate at the optimal efficiencies expected of naturally occurring stop codons. To investigate whether this could result in physiologically significant levels of read through, we examined the suppression of premature translation… CONTINUE READING

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