Premature separation of centromere and aneuploidy: an indicator of high risk in unaffected individuals from familial breast cancer families?

@article{Rao1996PrematureSO,
  title={Premature separation of centromere and aneuploidy: an indicator of high risk in unaffected individuals from familial breast cancer families?},
  author={N. Mallikarjuna Rao and Narendra N. Joshi and Shashank R. Shinde and Suresh Advani and Soma N. Ghosh},
  journal={European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation},
  year={1996},
  volume={5 5},
  pages={
          343-50
        }
}
It is estimated that one in every four women with a first-degree relative affected by breast cancer will develop the disease. Recent evidence suggests that susceptibility to breast cancer can be inherited. We have carried out cytogenetic analysis on PHA-stimulated lymphocyte cultures of breast cancer patients (familial and sporadic), patients with benign breast lesions, unaffected individuals from families with a history of breast cancer and healthy controls. A high incidence of premature… CONTINUE READING