Premature senescence of mesothelial cells is associated with non-telomeric DNA damage.

@article{Ksiek2007PrematureSO,
  title={Premature senescence of mesothelial cells is associated with non-telomeric DNA damage.},
  author={Krzysztof Książek and Jo{\~a}o F. Passos and Sharon Olijslagers and Gabriele Saretzki and Carmen M. Martin-Ruiz and Thomas von Zglinicki},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={362 3},
  pages={707-11}
}
Human peritoneal mesothelial cells (HPMCs) senesce in vitro after barely few population doublings. In this report, we show that senescence of HPMCs is associated with increased accumulation of gamma-H2A.X foci, which reveal DNA double-strand breaks. Of note, already early-passage cultures contain a considerable fraction (44+/-10%) of cells bearing gamma-H2A.X foci. The gamma-H2A.X foci localize predominantly to non-telomeric DNA, either in young or senescent cells. Moreover, HPMCs seem to have… CONTINUE READING

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