Premature senescence of mesenchymal stem cells: causes and preventive measures

@article{Zhou2018PrematureSO,
  title={Premature senescence of mesenchymal stem cells: causes and preventive measures},
  author={Long Zhou and Fan He and Lisy Wang},
  journal={Journal of Clinical Rehabilitative Tissue Engineering Research},
  year={2018},
  volume={22},
  pages={4721–4728}
}
BACKGROUND: Mesenchymal stem cells (MSCs) have strong self-renewal and multi-directional differentiation potential, which have been widely applied in the tissue engineering and regenerative medicine. However, it is inevitable to face the aging of MSCs during in vitro amplification. OBJECTIVE: To elucidate the characteristics and causes of premature senescence of MSCs, and to summarize the measures to prevent the aging of MSCs in recent years, so as to explore a safe and effective method for… CONTINUE READING

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