Premature p34cdc2 activation required for apoptosis.

@article{Shi1994PrematurePA,
  title={Premature p34cdc2 activation required for apoptosis.},
  author={Lianfa F. Shi and Walter K Nishioka and John P. H. Th'ng and E. Morton Bradbury and David W. Litchfield and Arnold H. Greenberg},
  journal={Science},
  year={1994},
  volume={263 5150},
  pages={
          1143-5
        }
}
Activation of the serine-threonine kinase p34cdc2 at an inappropriate time during the cell cycle leads to cell death that resembles apoptosis. Premature activation of p34cdc2 was shown to be required for apoptosis induced by a lymphocyte granule protease. The kinase was rapidly activated and tyrosine dephosphorylated at the initiation of apoptosis. DNA fragmentation and nuclear collapse could be prevented by blocking p34cdc2 activity with excess peptide substrate, or by inactivating p34cdc2 in… CONTINUE READING
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