Premature ovarian failure.

  title={Premature ovarian failure.},
  author={Svetlana Vujovi{\'c} and Miomira S Ivovi{\'c} and Milina Tan{\vc}i{\'c}-Gaji{\'c} and Ljiljana V Marina and Marija Bara{\'c} and Zorana Arizanovi{\'c} and Ana Nenezi{\'c} and Maja Franic Ivanisevic and Jelena Mici{\'c} and Silvija Saji{\'c} and Dragan V Micic},
  journal={Srpski arhiv za celokupno lekarstvo},
  volume={140 11-12},
Premature ovarian failure (POF) is the occurrence of hypergonadotropic hypoestrogenic amenorrhea in women under the age of forty years. It is idiopathic in 74-90% patients. Known cases can be divided into primary and secondary POF. In primary POF genetic aberrations can involve the X chromosome (monosomy, trisomy, translocations, deletions) or autosomes. Genetic mechanisms include reduced gene dosage and non-specific chromosome effects impairing meiosis, decreasing the pool of primordial… CONTINUE READING


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