Premature ovarian failure: its relationship to autoimmune disease.

  title={Premature ovarian failure: its relationship to autoimmune disease.},
  author={Michael M. Alper and Patricia A. Garner},
  journal={Obstetrics and gynecology},
  volume={66 1},
Thirty-three patients with the diagnosis of chromosomally competent premature ovarian failure were reviewed for evidence of autoimmune disease. Thirty-nine percent of subjects had an associated autoimmune disorder, of which thyroid disease was the most common. One patient had vitiligo and one had adrenal insufficiency. A family history of autoimmune disease was elicited from 18% of subjects, all of whom proved to have an autoimmune disease themselves. From these findings, and a review of other… CONTINUE READING