Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.

@article{SchusterGossler2007PrematureMD,
  title={Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.},
  author={Karin Schuster-Gossler and Ralf Cordes and Achim Gossler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 2},
  pages={
          537-42
        }
}
In vertebrates, skeletal myogenesis is initiated by the generation of myoblasts followed by their differentiation to myocytes and the formation of myofibers. The determination of myoblasts and their differentiation are controlled by muscle regulatory factors that are activated at specific stages during myogenesis. During late embryonic and fetal stages a distinct population of resident proliferating progenitor cells is the major source of myogenic cells. How the differentiation of myoblasts and… CONTINUE READING

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Cell Tissue Res 296:175–182

  • S Dietrich
  • 1999
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