Premature mortality in autism spectrum disorder

@article{Hirvikoski2016PrematureMI,
  title={Premature mortality in autism spectrum disorder},
  author={Tatja Hirvikoski and Ellenor Mittendorfer-Rutz and Marcus Boman and Henrik Larsson and Paul Lichtenstein and Sven B{\"o}lte},
  journal={British Journal of Psychiatry},
  year={2016},
  volume={208},
  pages={232 - 238}
}
Background Mortality has been suggested to be increased in autism spectrum disorder (ASD). Aims To examine both all-cause and cause-specific mortality in ASD, as well as investigate moderating role of gender and intellectual ability. Method Odds ratios (ORs) were calculated for a population-based cohort of ASD probands (n = 27 122, diagnosed between 1987 and 2009) compared with gender-, age- and county of residence-matched controls (n = 2 672 185). Results During the observed period, 24 358 (0… 
View on Cambridge Press
cambridge.org
413 Citations
Highly Influential Citations
25
Background Citations
135
Methods Citations
3
Results Citations
18

413 Citations

Citation Type

Citation Type

Mortality and cause of death of Australians on the autism spectrum
TLDR
A differing profile of top causes of death was found for autistic individuals relative to the general population, with “nervous system and sense disorders” and “injury and poisoning” being the top‐ranked causes for those on the spectrum.
Mortality in individuals with autism spectrum disorder: Predictors over a 20-year period
TLDR
The results suggest the importance of social engagement and functional self-sufficiency across the life course, as well as adequate access to health care for individuals with autism spectrum disorder.
Age at death and comorbidity of dementia-related disorders among individuals with autism spectrum disorder
TLDR
Examination of the mean age at death of individuals with ASD and subsequent comorbidity with Alzheimer’s disease, and any form of dementia, as a whole and according to sex indicates males with ASD were significantly more likely to have acquired Alzheimer's disease or a forms of dementia as compared to females with ASD.
Risk for Premature Mortality and Intentional Self-harm in Autism Spectrum Disorders
TLDR
While ASD subjects die of suicide and present with more self-harm, the association is explained by comorbid psychiatric disorders.
Mortality in 787,666 school pupils with and without autism: A cohort study
TLDR
The death rate in the current generation of children and young adults with autism is no higher than for other children, but that even in this high-income country, some deaths could have been avoided by better care and may have been prevented by high quality care.
Prevalence and Premature Mortality Statistics of Autism Spectrum Disorder Among Children in Korea: A Nationwide Population-Based Birth Cohort Study
TLDR
The present study demonstrated that national-level prevalence and mortality statistics of ASD can be estimated effectively using claims data comprising newborns born each year and followed up for to the age of interest.
A 20‐year study of suicide death in a statewide autism population
TLDR
Understanding of suicide risk in ASD is expanded and the need for additional population‐based research into suicide attempts and ideation, as well as exploration of additional risk factors, is pointed to.
Mortality in Persons With Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-analysis.
TLDR
This systematic review and meta-analysis found that ASD and ADHD are associated with a significantly increased risk of mortality.
Individual risk and familial liability for suicide attempt and suicide in autism: a population-based study
TLDR
Clinicians treating patients with ASD should be vigilant for suicidal behaviour and consider treatment of psychiatric comorbidity, especially in comparison to controls.
Autism and autistic traits in those who died by suicide in England.
TLDR
Elevated autistic traits are significantly over-represented in those who die by suicide, with groups experiencing a comparably high number of multiple risk markers before they died.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
Mortality and causes of death in autism spectrum disorders
TLDR
The mortality risk among those with ASD was nearly twice that of the general population and the SMR was particularly high in females, which should focus on better managing of the complex relationships between ASD and physical illness to prevent avoidable deaths.
Excess Mortality and Causes of Death in Autism Spectrum Disorders: A Follow up of the 1980s Utah/UCLA Autism Epidemiologic Study
TLDR
The elevated mortality risk associated with ASD in the study cohort appeared related to the presence of comorbid medical conditions and intellectual disability rather than ASD itself suggesting the importance of coordinated medical care for this high risk sub-population of individuals with ASD.
Mortality in Autism: A Prospective Longitudinal Community-Based Study
TLDR
The mortality rate in a representative group of individuals born in the years 1962–1984, diagnosed with autism/atypical autism in childhood and followed up at young adult age, was established, and the risk factors and causes of death were examined.
Autism Spectrum Disorders in the Stockholm Youth Cohort: Design, Prevalence and Validity
TLDR
The design of a large intergenerational resource for ASD research is presented, along with population-based prevalence estimates of ASD and their diagnostic validity, and findings accords with recently reported prevalence estimates from Western countries at around 1.
The epidemiology and global burden of autism spectrum disorders
TLDR
There was no clear evidence of a change in prevalence for autistic disorder or other ASDs between 1990 and 2010 and Worldwide, there was little regional variation in the prevalence of ASDs.
Migration and autism spectrum disorder: population-based study
TLDR
Investigating the relationship between parental migration status and risk of autism spectrum disorder, taking into consideration the importance of region of origin, timing of migration and possible discrepancies in associations between autism subtypes concluded that environmental factors associated with migration may contribute to the development of autism presenting with comorbid intellectual disability.
Causes of Death in Autism
TLDR
Elevated death rates were observed for several causes, including seizures and accidents such as suffocation and drowning; elevated mortality due to respiratory disease was observed among persons with severe mental retardation.
Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort.
TLDR
It is confirmed that advancing parental age increases risk of ASD, particularly for ASD with ID, in a manner dependent on co-parental age, and an increase of n years in maternal age has greater implications for ASD risk than a similar increase in paternal age.
Mortality and Causes of Death in Pervasive Developmental Disorders
TLDR
Rediagnosed and followed a clinical sample of 341 children with related pervasive developmental disorders for an average of 24 years, with both severe retardation and normal intelligence being associated with a relatively high risk of death.
The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood.
TLDR
Different neuropsychiatric disorders seem to have a common genetic etiology, suggesting caution in the use of diagnostic entities and proband status in efforts to uncover genes predisposing to autism spectrum disorders.
...
1
2
3
4
5
...