Premature ejaculation: a clinical update

  title={Premature ejaculation: a clinical update},
  author={Neil R Palmer and Bronwyn GA Stuckey},
  journal={Medical Journal of Australia},
Premature ejaculation (PE) is ejaculation occurring without control, on or shortly after vaginal penetration and before the subject wishes it, causing marked distress or interpersonal difficulties. PE is the most common male sexual complaint. Primary (lifelong) PE has a physiological basis. Therapy should involve the man and his partner. The primary aims of therapy are for the man to regain a sense of control over his ejaculation time and for him and his partner to feel satisfaction with sexual… 

Premature Ejaculation: Aetiology and Treatment Strategies

Patients with lifelong and acquired PE are most likely to benefit from combination therapy of pharmacological treatment in the form of selective serotonin re-uptake inhibitor dapoxetine, psychosexual behavioural therapy and psychological therapy.

Premature Ejaculation

When rapid ejaculation causes a distress, it is a sexual dysfunction deserving medical and/or psycho-sexological management currently evidence-based.

Dapoxetine: a pharmacological therapy for the treatment of premature ejaculation

Dapoxetine (30 and 60 mg) significantly increased mean IELT across the trials (p ≤ 0.001 both doses vs placebo) up to 24 weeks, and was accompanied by improvements in patient-reported outcomes (control, satisfactio...

Dapoxetine: a pharmacological therapy for the treatment of premature ejaculation

This definition is applicable only to men with lifelong PE, as there are currently insufficient robust data available to propose an evidence-based definition of acquired PE.

Premature Ejaculation Re-Visited: Definition and Contemporary Management Approaches

Interest in the definition and management of premature ejaculation (PE) has been increasing significantly among all healthcare professionals and its clinical perceptions continue to evolve in recent

Etiology of Premature Ejaculation

The etiology of premature ejaculation is not well understood and from an etiological and therapeutic viewpoint, it is useful to distinguish between primary (lifelong, from the onset of sexual functioning) and secondary premature ejaculations (acquired after a period of normal sexual functioning).

Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation.

It is concluded that using tramadol hydrochloride at different doses on demand for the treatment of PE is effective, safe and tolerable, with minimal undesirable effects, and approval for this indication should be sought.

Premature ejaculation in patients with lower urinary tract symptoms: a systematic review

Most of the studies showed a significant relationship between LUTS and PE, and there is a possible association between PE and LUTs.

Tratamiento de la eyaculación precoz. Punto de vista del internista

In a recent clinical trial conducted in Mexico city, paroxetine at daily doses of 15 and 20 mg, was found to be effective and safe for the treatment of PE; observing significant statistical differences in the IELT and PE index compared with placebo.

A Comparative Study of the Efficacy of Levosulpiride versus Paroxetine in Premature Ejaculation

Both agents are efficacious in patients of PME but paroxetine is more efficacious than levosulpiride, a lesser studied and used drug hence more research should be done for it.



Premature ejaculation: state of the art.

  • M. Waldinger
  • Psychology, Medicine
    The Urologic clinics of North America
  • 2007

Guidelines for the diagnosis and management of premature ejaculation.

  • I. Sharlip
  • Medicine
    The journal of sexual medicine
  • 2006
Condensed guidelines for the diagnosis and treatment of PE are presented and each of these two documents recognizes that diagnosis involves a shortened intravaginal latency time as well as patient reports of poor control over ejaculation and patient distress over the condition.

From Kama Sutra to The history, myths and management of premature ejaculation

As long as man has breathed, his quest for the perfect sexual experience seems to have eluded him. Often the experience has been brought to an abrupt end by the misery of premature ejaculation. This

Interrelationships among measures of premature ejaculation: the central role of perceived control.

The patient's perception of control over ejaculation is central to understanding how PE is associated with satisfaction with sexual intercourse and ejaculation-related distress.

A multinational population survey of intravaginal ejaculation latency time.

The distribution of the Intravaginal ejaculation latency time (IELT) in all the five countries was positively skewed, with a median IELT of 5.4 minutes but with differences between countries, which was significantly different from each of the other countries.

Guidelines for the pharmacotherapy of premature ejaculation

  • P. Assalian
  • Medicine, Psychology
    World Journal of Urology
  • 2004
These guidelines were developed to ensure that medication are used when clear indications are present and are clearly shown that rapid ejaculation can be treated quickly and effectively with clomipramine and SSRIs.

Treatment of premature ejaculation with paroxetine hydrochloride

Paroxetine hydrochloride appears to be a useful agent in the pharmacological treatment of premature ejaculation when administered on a chronic, an ‘ on-demand’ basis following chronic treatment or initial ‘on demand” basis.

The majority of men with lifelong premature ejaculation prefer daily drug treatment: an observation study in a consecutive group of Dutch men.

A group of Dutch men with lifelong PE favor uninterrupted daily drug treatment to delay ejaculation mainly because daily treatment guarantees no interference with the spontaneity of having sex.

Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation.

Although IELT and VTS-ELT were not significantly improved, sildenafil increased confidence, the perception of ejaculatory control, and overall sexual satisfaction, and decreased the refractory time to achieve a second erection after ejaculation in men with PE.