Premature chromosome condensation associated with fluorescence in situ hybridisation detects cytogenetic abnormalities after a CT scan: evaluaton of the low-dose effect.

@article{Mkacher2003PrematureCC,
  title={Premature chromosome condensation associated with fluorescence in situ hybridisation detects cytogenetic abnormalities after a CT scan: evaluaton of the low-dose effect.},
  author={Radhia M'kacher and Dominique Violot and Bernard Aubert and Th{\'e}odore Girinsky and Julien Dossou and Nadine B{\'e}ron-Gaillard and Patrice P Carde and C. Parmentier},
  journal={Radiation protection dosimetry},
  year={2003},
  volume={103 1},
  pages={35-40}
}
The purpose of this study was to assess the cytogenetic effects of the X ray irradiation used during a CT scan in order to estimate the mean absorbed dose in circulating lymphocytes. Chromosomal aberrations were scored in blood lymphocytes of ten patients undergoing CT scans, by applying fluorescence in situ hybridisation (FISH) to metaphase cells and premature chromosome condensation (PCC) with chromosomes 1, 3 and 4 painting probes immediately after exposure. This generated a dosimetric index… CONTINUE READING

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