Premature chromatin condensation caused by loss of RCC1.

  title={Premature chromatin condensation caused by loss of RCC1.},
  author={Hitoshi Nishijima and Takashi Seki and Hideki Nishitani and Takako Nishimoto},
  journal={Progress in cell cycle research},
Hamster rcc1 mutant, tsBN2, prematurely enter mitosis during S phase. RCC1 is a guanine nucleotide exchanging factor for a small G protein Ran and localised on the chromatin, whereas RanGTPase activating protein is in the cytoplasm. Consistently, Ran shuttles between the nucleus and the cytoplasm, carrying out nucleus-cytosol exchange of macromolecules, which regulates the cell cycle. The finding that loss of RCC1 which disturbs nuclear protein export due to loss of RanGTP, abrogates the check… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.