Premature chromatin condensation caused by loss of RCC1.

@article{Nishijima2000PrematureCC,
  title={Premature chromatin condensation caused by loss of RCC1.},
  author={Hitoshi Nishijima and Takashi Seki and Hideki Nishitani and Takako Nishimoto},
  journal={Progress in cell cycle research},
  year={2000},
  volume={4},
  pages={
          145-56
        }
}
Hamster rcc1 mutant, tsBN2, prematurely enter mitosis during S phase. RCC1 is a guanine nucleotide exchanging factor for a small G protein Ran and localised on the chromatin, whereas RanGTPase activating protein is in the cytoplasm. Consistently, Ran shuttles between the nucleus and the cytoplasm, carrying out nucleus-cytosol exchange of macromolecules, which regulates the cell cycle. The finding that loss of RCC1 which disturbs nuclear protein export due to loss of RanGTP, abrogates the check… CONTINUE READING

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