Premature aging of T cells is associated with faster HIV-1 disease progression.

@article{Cao2009PrematureAO,
  title={Premature aging of T cells is associated with faster HIV-1 disease progression.},
  author={Weiwei Cao and Beth D. Jamieson and Lance E. Hultin and Patricia M. Hultin and Rita B. Effros and Roger Detels},
  journal={Journal of acquired immune deficiency syndromes},
  year={2009},
  volume={50 2},
  pages={
          137-47
        }
}
OBJECTIVE To determine if untreated HIV-1 infection and progression is associated with premature aging of memory CD8 and CD4 T cells and naive CD4 T cells. METHODS Twenty HIV-1-infected fast progressors and 40 slow progressors were included in our study, using risk set sampling. The expression of cell surface markers reflecting the differentiation stages of lymphocytes was measured using flow cytometry analyses performed on cryopreserved peripheral blood mononuclear cells. RESULTS We found… CONTINUE READING

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