Premature aging changes in neuromuscular junctions of transgenic mice with an extra human CuZnSOD gene: a model for tongue pathology in Down's syndrome.

@article{Yarom1988PrematureAC,
  title={Premature aging changes in neuromuscular junctions of transgenic mice with an extra human CuZnSOD gene: a model for tongue pathology in Down's syndrome.},
  author={R. Yarom and Dan Sapoznikov and Y. Havivi and Karen B. Avraham and Matthew A. Schickler and Yoram Groner},
  journal={Journal of the neurological sciences},
  year={1988},
  volume={88 1-3},
  pages={41-53}
}
We examined the tongue muscles in several strains of transgenic mice carrying the human Zn-Cu superoxide dismutase (CuZnSOD) gene. The presence of the extra gene was confirmed in mated progeny and the gene product activity was measured in the tongue and found to be much higher than in normal littermate controls. Using electron microscopic morphometry, the neuromuscular junctions of the transgenic mice showed significant changes resembling excessive aging, with atrophy, degeneration, withdrawal… CONTINUE READING

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