Premature Menopause in Patients with BRCA1 Gene Mutation

@article{Rzepkagrska2006PrematureMI,
  title={Premature Menopause in Patients with BRCA1 Gene Mutation},
  author={I. Rzepka-g{\'o}rska and B Tarnowski and Anita Chudecka-Głaz and Bohdan G{\'o}rski and Dorota Zielińska and Aleksandra Tołoczko-Grabarek},
  journal={Breast Cancer Research and Treatment},
  year={2006},
  volume={100},
  pages={59-63}
}
This study was undertaken with regard to the gonadotropin theory of ovarian cancer advocated in the literature and was designed to disclose specific features of ovarian morphology in carriers of the BRCA1 gene mutation. We enrolled 171 patients and divided them into two groups: A (n=90)—operated for breast cancer (30 patients with and 60 without the BRCA1 mutation); B (n=81)—with the BRCA1 mutation qualified for preventive adnexectomy. According to the authors’ classification described herein… Expand
Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation.
TLDR
Women who carry a BRCA mutation experience menopause earlier, on average, than women who do not have a mutation, but the difference is small and does not appear to affect fertility. Expand
Fertility and Pregnancy Counseling of Breast Cancer Patients with Germline BRCA Mutations
TLDR
Based on both the unique features and needs of these patients as well as the limited evidence on the performance of fertility preservation strategies and on the safety of having a pregnancy following the end of anticancer treatments, oncofertility counseling is particularly complex in young women with newly diagnosed BRCA-mutated breast cancer. Expand
Association of BRCA Mutations and Anti-müllerian Hormone Level in Young Breast Cancer Patients
TLDR
Fertility preservation should be considered more aggressively in young breast cancer patients with BRCA mutation, particularly in young, reproductive-aged patients with breast cancer who have significantly lower serum AMH level. Expand
Do BRCA1/2 mutation carriers have an earlier onset of natural menopause?
TLDR
Various types of selection bias hamper the comparison of ANM between BRCA1/2 mutation carriers and noncarriers, genetically tested in the clinic. Expand
BRCA1 germline mutations may be associated with reduced ovarian reserve.
TLDR
BRCA1 carriers have lower age- and BMI-adjusted serum AMH levels compared with women without BRCA mutations, and this results contribute to the current body of literature regarding BRCa carriers and their reproductive outcomes. Expand
Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis
TLDR
This meta-analysis evaluates whether women carrying BRCA mutations (BRCAm) have decreased ovarian reserve, in terms of Anti-Muellerian Hormone (AMH), compared to women without BRCAm (wild-type) to find a trend of reduced AMH level. Expand
Influence of BRCA Mutations on the Reproductive Potential of Women. A Systematic Review
TLDR
The review of the literature does not show differences when evaluating the response of BRCA carriers to an ovarian stimulation protocol, and the revision seems to show slight differences in the ovarian reserve. Expand
Premature ovarian aging in BRCA carriers: a prototype of systemic precocious aging?
TLDR
The results suggest a link between BRCA mutation, accelerated ovarian aging and systemic aging-related pathophysiology. Expand
Effects of BRCA gene mutation on female reproductive potential: A systematic review.
TLDR
In conclusion, there is no compelling evidence indicating that the rate of nulliparity, serum AMH, antral follicle counts and ovarian response are affected in BRCA mutation carriers. Expand
[Breast and ovarian cancer due to BRCA1&2 hereditary cancer predisposition syndrome and reproduction: literature review].
TLDR
Pregnancy and lactation have no effect on breast and ovaries or even decreases the risk, and infertility treatments do not increase breast and ovarian risk, according to a review of the international literature from the PubMed database. Expand
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