Premature Ejaculation

@article{Waldinger2012PrematureE,
  title={Premature Ejaculation},
  author={Marcel D. Waldinger},
  journal={Drugs},
  year={2012},
  volume={67},
  pages={547-568}
}
Premature ejaculation (PE) is a frequent male sexual complaint that is mediated mainly by disturbances of serotonergic neurotransmission and certain serotonin (5-HT) receptors and, to a lesser extent, oxytocinergic neurotransmission in the CNS.The current Diagnostic Manual of Mental Disorders (fourth edition, revised text) [DSM-IV-TR] definition of PE has a low positive predictive value and is inadequate for clinical, epidemiological and drug treatment research. Categorisation of PE into four… Expand
Evaluation of Premature Ejaculation
TLDR
The progress in PE research is discussed including evidence based evaluation methods and the classification of PE into four PE subtypes is relevant for pharmacotherapy and counseling of men with complaints of PE. Expand
Premature Ejaculation: 2020 Update
TLDR
Although the pathophysiology of these four PE syndromes has not been completely elucidated yet, pharmacotherapy must be considered the treatment of choice for lifelong PE patients whereas treating the underlying pathology must be the initial goal for patients with acquired PE. Expand
Treatment of Premature Ejaculation with Selective Serotonin Re-Uptake Inhibitors
TLDR
A meta-analysis has shown that the strongest ejaculation delaying effect of the SSRIs is produced by daily treatment with paroxetine, and that on-demand use of SSRI gives rise to much less ejaculation delay. Expand
A review on premature ejaculation
TLDR
A Large number of the patients suffering from permanent PE need medication and this literature review aims to review and cumulate the existing data in this regard and provide an informative conclusion. Expand
Treatment of Premature Ejaculation
TLDR
Current treatments of PE with their advantages and disadvantages are discussed including daily treatment with SSRIs, on-demand treatment with oral drugs and topical anesthetics, and psychosocial treatments. Expand
Ejaculatio praecox, erectio praecox, and detumescentia praecox as symptoms of a hypertonic state in lifelong premature ejaculation: A new hypothesis
  • M. Waldinger
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • 2014
TLDR
It will be argued that lifelong PE is characterized not only by early ejaculations, a diminished control over ejaculation, and negative personal consequences, but also by early erections and an immediately occurring detumescence of the penis after ejaculation as symptoms of an (sub)acute hypertonic or hypererotic physical state when making love. Expand
Future Treatments of Premature Ejaculation
TLDR
It is suggested that future research should not only focus on finding more detailed features of lifelong PE but should also focus on find clinical differences among the four PE subtypes, to increase the odds to find new therapeutic targets. Expand
Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation.
TLDR
The updated version of 2009 European Association of Urology guidelines on ED and PE are presented to present, summarising the present information onED and PE. Expand
Considerations for an evidence-based definition of premature ejaculation in the DSM-V.
  • R. Segraves
  • Psychology, Medicine
  • The journal of sexual medicine
  • 2010
TLDR
It is recommended that the Diagnostic and Statistical Manual committee adopt criteria similar to those adopted by the International Society of Sexual Medicine, and lifelong PE in heterosexual men be defined as ejaculation occurring within approximately 1 minute of vaginal penetration on 75% of occasions for at least 6 months. Expand
Evaluation of tramadol on demand vs. daily paroxetine as a long-term treatment of lifelong premature ejaculation.
TLDR
Daily paroxetine is more effective than on-demand tramadol for treatment of lifelong PE, and tramadol is not recommended as a long-term treatment of lifetime PE. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 197 REFERENCES
Emerging drugs for premature ejaculation
TLDR
Animal studies have shown that strong, immediate ejaculation delay may be induced by the combination of an SSRI with a 5-HT1A receptor antagonist, which may form the basis for the development of new on-demand drugs to treat PE. Expand
Lifelong premature ejaculation: definition, serotonergic neurotransmission and drug treatment
TLDR
Based on fundamental insights into serotonergic neurotransmission, it is suggested that on-demand conventional SSRI treatment will not lead to similarly impressive ejaculation delay as that found after daily conventional SSri treatment. Expand
Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system
TLDR
The neurophysiology and the peripheral neuroanatomy of ejaculation is described and a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections is provided. Expand
Lifelong premature ejaculation: from authority‐based to evidence‐based medicine
TLDR
Control trials with selective serotonin reuptake inhibitors, clomipramine and anaesthetic ointments have repeatedly shown the efficacy of both daily and 'as-needed' drug treatment to delay ejaculation. Expand
Utility of selective serotonin reuptake inhibitors in premature ejaculation.
TLDR
It is proposed that drug treatment of premature ejaculation should consist of 5-hydroxytryptamine (5-HT)2c receptor stimulation and/or 5-HT1A receptor inhibition, and it is postulated that acute treatment with SSRIs will not produce an ejaculation delay equivalent to that induced by daily treatment ofSSRIs. Expand
Lifelong premature ejaculation: current debate on definition and treatment
TLDR
Data of recent epidemiological stopwatch research of the intravaginal ejaculation latency time (IELT) support an ejaculation distribution theory, of a continuum of IELT in the general male population. Expand
An open clinical trial of fluoxetine in the treatment of premature ejaculation.
TLDR
The data suggest that serotonergic antidepressants may be effective in treating rapid ejaculation in men and underline the need to carry out a double-blind, placebo-controlled trial to confirm these results. Expand
AUA guideline on the pharmacologic management of premature ejaculation.
TLDR
Recommendations on the use of medications currently available in the United States are provided, based on a consensus of expert opinion following review of the literature, which assumes the absence of partner sexual dysfunction. Expand
Animal models of ejaculatory behavior.
TLDR
These preclinical studies may contribute to a better understanding of the neurobiology of ejaculation and help the development of novel drug targets to treat ejaculatory disorders such as premature ejaculation. Expand
The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study
TLDR
The patients treated with citalopram showed significantly greater improvement compared to the patients receiving placebo, and with respect to the subscales of the YSFI-II scale, similar overall significant improvements were seen in the patients given cITALopram compared to those given placebo. Expand
...
1
2
3
4
5
...