Premature Discontinuation of Randomized Trials in Critical and Emergency Care: A Retrospective Cohort Study.

  title={Premature Discontinuation of Randomized Trials in Critical and Emergency Care: A Retrospective Cohort Study.},
  author={Stefan Schandelmaier and Erik von Elm and John J. You and Anette Bl{\"u}mle and Yuki Tomonaga and François Lamontagne and Ramon T Saccilotto and Alain Amstutz and Theresa Bengough and Joerg J Meerpohl and Mihaela Stegert and Kelechi Kalu Olu and Kari A. O. Tikkinen and Ignacio Neumann and Alonso Carrasco-Labra and Markus Faulhaber and Sohail M. Mulla and Dominik Mertz and Elie A. Akl and Xin Sun and Dirk Bassler and Jason Walter Busse and Ignacio Ferreira-Gonz{\'a}lez and Alain Nordmann and Viktoria Luise Gloy and Heike Raatz and Lorenzo Moja and Rachel Rosenthal and Shanil Ebrahim and Per Olav Vandvik and Bradley C. Johnston and Martin A. Walter and Bernard Burnand and Matthias Schwenkglenks and Lars G Hemkens and Deborah J Cook and Maureen O. Meade and Heiner C. Bucher and Benjamin Kasenda and Matthias Briel},
  journal={Critical care medicine},
  volume={44 1},
OBJECTIVES Randomized clinical trials that enroll patients in critical or emergency care (acute care) setting are challenging because of narrow time windows for recruitment and the inability of many patients to provide informed consent. To assess the extent that recruitment challenges lead to randomized clinical trial discontinuation, we compared the discontinuation of acute care and nonacute care randomized clinical trials. DESIGN Retrospective cohort of 894 randomized clinical trials… CONTINUE READING
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