Premature Aging in Mice Deficient in DNA Repair and Transcription

  title={Premature Aging in Mice Deficient in DNA Repair and Transcription},
  author={J. de Boer and Jaan Olle Andressoo and J. de Wit and J. Huijmans and R. B. Beems and H. van Steeg and G. Weeda and G. V. D. van der Horst and W. V. van Leeuwen and A. Themmen and M. Meradji and J. Hoeijmakers},
  pages={1276 - 1279}
  • J. de Boer, Jaan Olle Andressoo, +9 authors J. Hoeijmakers
  • Published 2002
  • Medicine, Biology
  • Science
  • One of the factors postulated to drive the aging process is the accumulation of DNA damage. [...] Key Result TTD mice were found to exhibit many symptoms of premature aging, including osteoporosis and kyphosis, osteosclerosis, early greying, cachexia, infertility, and reduced life-span. TTD mice carrying an additional mutation in XPA, which enhances the DNA repair defect, showed a greatly accelerated aging phenotype, which correlated with an increased cellular sensitivity to oxidative DNA damage. We hypothesize…Expand Abstract
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