Premature Aging in Mice Deficient in DNA Repair and Transcription

@article{deBoer2002PrematureAI,
  title={Premature Aging in Mice Deficient in DNA Repair and Transcription},
  author={Johan G de Boer and Jaan-Olle Andressoo and Jan de Wit and Jan G. M. Huijmans and Rudolf B. Beems and Harry van Steeg and Geert Weeda and Gijsbertus T J van der Horst and Wibeke J. Van Leeuwen and Axel P. N. Themmen and Morteza Meradji and Jan H. J. Hoeijmakers},
  journal={Science},
  year={2002},
  volume={296},
  pages={1276 - 1279}
}
One of the factors postulated to drive the aging process is the accumulation of DNA damage. [] Key Result TTD mice were found to exhibit many symptoms of premature aging, including osteoporosis and kyphosis, osteosclerosis, early greying, cachexia, infertility, and reduced life-span. TTD mice carrying an additional mutation in XPA, which enhances the DNA repair defect, showed a greatly accelerated aging phenotype, which correlated with an increased cellular sensitivity to oxidative DNA damage. We hypothesize…

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