Premalignant and in situ breast disease: biology and clinical implications.

  title={Premalignant and in situ breast disease: biology and clinical implications.},
  author={Grazia Arpino and Rodolfo Laucirica and Richard M. Elledge},
  journal={Annals of internal medicine},
  volume={143 6},
Most types of invasive breast cancer are thought to evolve over long periods from specific preexisting benign lesions. Of the many types of benign entities found in the human breast, only a few have clinically significant premalignant potential. Currently, the best-characterized premalignant lesions are atypical ductal hyperplasia, atypical lobular hyperplasia, and lobular carcinoma in situ. Ductal carcinoma in situ is considered to be a preinvasive malignant lesion. Two additional lesions… CONTINUE READING