Preliminary study of the pharmacokinetics of desmethyldiazepam administered as drops or tablets.

@article{Yeates1986PreliminarySO,
  title={Preliminary study of the pharmacokinetics of desmethyldiazepam administered as drops or tablets.},
  author={Rodney A. Yeates and H. Laufen and Kevin Raeder and M. Leitold},
  journal={Arzneimittel-Forschung},
  year={1986},
  volume={36 1},
  pages={138-40}
}
Desmethyldiazepam (Vegesan) was administered in the form of 5-mg and 10-mg tablets and of 10-mg drops to 4 male and 4 female young healthy volunteers. The plasma levels of desmethyldiazepam were measured over 168 h. The time courses could be fitted to the one- or to the two-compartment model. The mean half-lives of elimination came to 75.3 +/- 32.0 (SD) h (5-mg tablets), 66.5 +/- 21.0 (SD) h (10-mg tablets) and 78.4 +/- 33.2 (SD) h (10-mg drops). The bioavailability of desmethyldiazepam from… CONTINUE READING

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