Gradient of distribution in Europe of the major CF mutation and of its associated haplotype
- V . Vavrova, A . de la Chapelle, E . Savilahti
- Human Genetics
Two RFLP's closely linked to the CF gene (KM.19/PstI and XV-2c/TaqI) have been analysed in a sample of CF families in which one or more affected children had been diagnosed by the CF Centre of Odessa. The most frequent haplotype in CF chromosomes (2-1) is the same observed with higher frequency in other populations. If confirmed on a larger sample of CF patients from the USSR, this result might be indicative of heterogeneity of mutations present in the Soviet population.