Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma.

@article{Lee2006PreliminaryRO,
  title={Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma.},
  author={Anne Wing-Mui Lee and Stewart Yuk Tung and Anthony Tak Cheung Chan and Rick Chappell and Yiu-Tong Fu and Tai-xiang Lu and Terence Tan and Daniel T T Chua and Brian O'Sullivan and Shirley L Xu and Ellie Suet-yee Pang and W M Sze and To-wai Leung and Wing-hong Kwan and Paddy T M Chan and Xiu-fang Liu and E. -H. Tan and Jonathan Shun-Tong Sham and Lillian L. Siu and Wai-hon Lau},
  journal={International journal of radiation oncology, biology, physics},
  year={2006},
  volume={66 1},
  pages={142-51}
}
PURPOSE To compare the benefit achieved by concurrent chemoradiotherapy (CRT) and/or accelerated fractionation (AF) vs. radiotherapy (RT) alone with conventional fractionation (CF) for patients with T3-4N0-1M0 nasopharyngeal carcinoma (NPC). METHODS AND MATERIALS All patients were irradiated with the same RT technique to > or =66 Gy at 2 Gy per fraction, conventional five fractions/week in the CF and CF+C (chemotherapy) arms, and accelerated six fractions/week in the AF and AF+C arms. The CF… CONTINUE READING
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