Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium.

@article{Sternberg1985PreliminaryRO,
  title={Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium.},
  author={Cora N Sternberg and Alexandre Yagoda and Howard I. Scher and Robin Caird Watson and T. M. Tanzeer Ahmed and Lora Rose Weiselberg and Nancy V Geller and Phyllis Hollander and Harry W. Herr and Pramod G. Sogani},
  journal={The Journal of urology},
  year={1985},
  volume={133 3},
  pages={
          403-7
        }
}
The M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) regimen was used to treat 25 patients with transitional cell carcinoma of the urothelial tract. Treatment consisted of monthly cycles of 30 mg. per m.2 methotrexate, followed 24 hours later by 3 mg. per m.2 vinblastine, 30 mg. per m.2 doxorubicin and 70 mg. per m.2 cisplatin, and concluded with repeat vinblastine and methotrexate on days 15 and 22. Significant tumor regression was noted in 71 per cent of the patients. Complete… CONTINUE READING
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