Preliminary results in quantitation of HLA-DRA by real-time PCR: a promising approach to identify immunosuppression in sepsis

@inproceedings{Cajander2013PreliminaryRI,
  title={Preliminary results in quantitation of HLA-DRA by real-time PCR: a promising approach to identify immunosuppression in sepsis},
  author={Sara Cajander and Anders B{\"a}ckman and Elisabet Tina and Kristoffer Str{\aa}lin and Bo S{\"o}derquist and Jan K{\"a}llman},
  booktitle={Critical care},
  year={2013}
}
INTRODUCTION Reduced monocyte human leukocyte antigen (mHLA)-DR surface expression in the late phase of sepsis is postulated as a general biomarker of sepsis-induced immunosuppression and an independent predictor of nosocomial infections. METHODS Fifty-nine patients with sepsis and blood culture growing pathogenic bacteria were studied. Blood samples were collected at day 1 or 2 after admission, for measurement of mHLA-DR by flow cytometry and mRNA expression of HLA-DRA and class II… CONTINUE READING

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