Preliminary report of the discovery of a new pharmaceutical granulation process using foamed aqueous binders.

@article{Keary2004PreliminaryRO,
  title={Preliminary report of the discovery of a new pharmaceutical granulation process using foamed aqueous binders.},
  author={Colin M Keary and Paul J Sheskey},
  journal={Drug development and industrial pharmacy},
  year={2004},
  volume={30 8},
  pages={831-45}
}
Spray granulation is commonly used to improve the flow of drug formulation powders by adding liquid binders. We have discovered a new granulation process whereby liquid binders are added as aqueous foam. Initial experiments indicate that foam granulations require less binder than spray granulations, less water is added to the powder mass, rates of addition of foam can be greater than rates of addition of sprayed liquids, and foam can be added in a single batch to the surface of the powder mass… CONTINUE READING

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