Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines

@article{Crawley1980PreliminaryRO,
  title={Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines},
  author={Jacqueline N. Crawley and Frederick K. Goodwin},
  journal={Pharmacology Biochemistry and Behavior},
  year={1980},
  volume={13},
  pages={167-170}
}
A simple system is described to analyze the possibility that increased exploratory behavior is an index for the anxiolytic effects of benzodiazepines in laboratory rodents. Mice were allowed free run in a two-chambered arena, where two-thirds of the area was illuminated and one-third was darkened. The two chambers were separated by a black partition equipped with photocells across the opening, and the entire cage rested on an Animex activity monitor. Transitions across the partition between the… Expand
Exploratory behavior models of anxiety in mice
  • J. Crawley
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
  • 1985
TLDR
Parameters of exploratory behaviors responsive to anti-anxiety drugs are reviewed with respect to their sensitivity and specificity for anxiolytics in mice, suggesting that rat models may be more sensitive to anxiogenic compounds than are mouse models. Expand
Distinguishing anxiolysis and hyperactivity in an open space behavioral test
TLDR
Amphetamine and diazepam produced an inverted U-shaped dose-response effect on different parameters of the test and it is demonstrated that the drug concentration which elicited a peak in mean number of entries is different from the drug Concentration which elicits apeak in mean duration of entries. Expand
The Anxiolytic and Anxiogenic Actions of Ethanol in a Mouse Model
TLDR
It is concluded that the simple model of anxiety described in the mouse may be useful for eludicating the mechanisms involved in the anxiolytic and anxiogenic potential of ethanol and may aid the search for novel agents having potential to suppress withdrawal anxiogenesis. Expand
Anxiolytic action of CGS 9896 on mouse exploratory behavior.
TLDR
Analysis of mouse exploratory model of anxiety data support the interpretation that CGS 9896 acts as an anxiolytic through the benzodiazepine receptor, and appears to have no sedating properties within the anxIOlytic dose range. Expand
Actions of sulpiride and tiapride in a simple model of anxiety in mice
TLDR
The "two-compartment activity box" is suggested to be a model sensitive to the actions of clinically-active anxiolytic compounds, as mice demonstrated a clear preference for the dim black section, a finding not inconsistent with the nocturnal nature of this species. Expand
A New Approach to the Light/Dark Test Procedure in Mice
TLDR
The light/dark test may be useful for identifying putative anxiolytic and anxiogenic agents, but an additional test such as an open field or an actimeter test must be performed as a control with regard to the problem of sedation and change in exploration. Expand
Further characterization of a simple, automated exploratory model for the anxiolytic effects of benzodiazepines
TLDR
The diazepam-induced increase in exploratory activity was significant over the first three uses of test animals and these data recommend reuse of mice to a maximum of three trials, throughout the daytime or evening hours of their lighting schedule. Expand
The mouse light/dark box test.
TLDR
The light/dark test may be useful to predict anxiolytic-like or anxiogenic-like activity in mice, and has the advantages of being quick and easy to use, without requiring the prior training of animals. Expand
A comparative study of the effects of ritanserin (R 55 667) and chlordiazepoxide on rat open field behavior
A rat open field test is described in which the inherent tendency of rats to explore an environment is titrated against their inherent tendency to avoid an open field that is large, brightlyExpand
A two-compartment exploratory model to study anxiolytic/anxiogenic effects of drugs in the rat.
The response of a recently described light/dark choice novelty situation to anxiolytic and non-anxiolytic agents as well as to putative anxiogenic drugs was assessed in rats. Diazepam (1.0-10.0Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 14 REFERENCES
A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats.
TLDR
All four benzodiazepines prevented aggressive behaviour in the mouse and rat at doses well below those required to produce analgesia or sedation, and all compounds were potent anticonvulsants, but showed greater activity against leptazoleinduced convulsion than against maximal electroshock-induced convulsions. Expand
Selective antagonism of isolation-induced aggression in mice by diazepam following chronic administration
  • J. Malick
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • 1978
TLDR
Diazepam was shown to be a selective antagonist of fighting in isolated mice following chronic administration for 5 days and selective tolerance rapidly developed to the general CNS depression produced by diazepam whereas the antifighting activity was not diminished and, in fact, tended to be enhanced following multiple drug administrations. Expand
Relationship between benzodiazepine receptors and experimental anxiety in rats
TLDR
Data implicate 3H-diazepam binding sites in mediating at least some of the anxiolytic properties of benzodiazepines and suggest the existence of some endogenous substance which might be involved in the etiology of anxiety. Expand
Exploratory activity: genetic analysis of its modification by scopolamine and amphetamine.
TLDR
Amphetamine exerted opposite effects in relation to those exerted by scopolamine on activity and its action was found to be determined by a polygenic system. Expand
A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants
  • S. File, J. Hyde
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • 1979
TLDR
The effects of minor tranquilisers and of stimulant drugs were studied in the Social Interaction test of anxiety: whereas phenobarbitone increased social interaction regardless of the test illuminance and unfamiliarity, the increase produced by flurazepam was limited to the more stressful test conditions. Expand
Putative endogenous ligands for the benzodiazepine receptor.
TLDR
Preliminary studies outlined below indicate that the purines are good candidates as putative endogenous ligands for the benzodiazepine receptor and provide a foundation for future studies that concern the homeostatic mediation of seizure activity and anxiety. Expand
An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain
TLDR
This work has reported the presence of a high affinity, saturable, stereospecific binding site for benzodiazepines in synaptic membrane preparations obtained from brain of different animal species, including man, and this high affinity binding is now used to determine the therapeutic potency and to study the mode of action of Benzodiazepine in anxiety. Expand
Nicotinamide is a brain constituent with benzodiazepine-like actions
TLDR
The isolation and benzodiazepine-like actions of nicotinamide are described, a compound which might exert these actions in the brain physiologically. Expand
Benzodiazepine receptors in rat brain
TLDR
Experiments suggest that another important group of psychoactive drugs, the benzodiazepines, bind to specific receptors on the membranes of rat brain cells, and this suggests that there may be an unknown endogenous neurotransmitter which is the natural ligand for the Benzodiazepine receptor. Expand
Dimensional analysis of activity and elimination in a genetically heterogeneous group of mice ()
TLDR
Factor and cluster analyses of the scores obtained suggest that five factors can account for the observed intercorrelations between measures and behaviour relating to barriers. Expand
...
1
2
...