Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis.

  title={Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis.},
  author={Shu Ye and Gerald F. M. Watts and Sundhiya Mandalia and Steve E Humphries and Adriano M. Henney},
  journal={British heart journal},
  volume={73 3},
Stromelysin is a member of the family of metalloproteinases that degrade extracellular matrix. In situ hybridisation and histopathological studies suggest that stromelysin activity may be important in the connective tissue remodelling processes associated with atherogenesis and plaque rupture. Single strand conformation polymorphism analysis identified a common polymorphism in the stromelysin gene promoter located 1171 bp upstream from the start of transcription in which one allele has a run of… CONTINUE READING


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