Preliminary pharmacokinetics of tramadol hydrochloride after administration via different routes in male and female B6 mice.

Abstract

OBJECTIVE 1) To determine the pharmacokinetics of tramadol hydrochloride and its active metabolite, O-desmethyltramadol (M1), after administration through different routes in female and male C57Bl/6 mice; 2) to evaluate the stability of tramadol solutions; and 3) to identify a suitable dose regimen for prospective clinical analgesia in B6 mice. STUDY… (More)
DOI: 10.1016/j.vaa.2016.09.007

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