Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

@article{CoustyBerlin1994PreliminaryPA,
  title={Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite},
  author={D. Cousty-Berlin and B. Bergaud and M. Bruyant and T. Battmann and C. Branche and D. Philibert},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1994},
  volume={51},
  pages={47-55}
}
The non-steroidal antiandrogens, RU 58841 and RU 56187 are amongst the most active of a new series of N-substituted aryl hydantoins or thiohydantoins. Their pharmacokinetics and principal metabolic profiles have been evaluated in rat plasma after intravenous administration of a 10 mg/kg dose. Both compounds disappear relatively rapidly from the plasma (elimination half-life of the order of 1 h), but they form a common metabolite, the N-desalkyl derivative, RU 56279, which is eliminated much… Expand
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