Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers.

@article{Fornasini1997PreliminaryPS,
  title={Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers.},
  author={G Fornasini and N. Marco Monti and G Brogin and Margherita Gallina and M. Eandi and Stefano Persiani and Massimo Bani and Chiara Della Pepa and Gabriella Zara and M S Strolin Benedetti},
  journal={Chirality},
  year={1997},
  volume={9 3},
  pages={297-302}
}
The pharmacokinetics of ibuprofen enantiomers were investigated in a crossover study in which seven healthy male volunteers received single oral doses of 800 mg racemic ibuprofen as a soluble granular formulation (sachet) containing L-arginine (designated trade name: Spedifen), 400 mg (-)R-ibuprofen arginine or 400 mg (+)S-ibuprofen arginine. Plasma levels… CONTINUE READING