Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers.

@article{Fornasini1997PreliminaryPS,
  title={Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers.},
  author={Gianfranco Fornasini and Nunzia Ceppi Monti and Giandomenico Brogin and M Gallina and M. Eandi and Stefano Persiani and Massimo Bani and Carlo Della Pepa and Gian Paolo Zara and Margherita Strolin Benedetti},
  journal={Chirality},
  year={1997},
  volume={9 3},
  pages={
          297-302
        }
}
The pharmacokinetics of ibuprofen enantiomers were investigated in a crossover study in which seven healthy male volunteers received single oral doses of 800 mg racemic ibuprofen as a soluble granular formulation (sachet) containing L-arginine (designated trade name: Spedifen), 400 mg (-)R-ibuprofen arginine or 400 mg (+)S-ibuprofen arginine. Plasma levels of both enantiomers were monitored up to 480 minutes after drug intake using an enantioselective analytical method (HPLC with ultraviolet… Expand
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A relationship between ibuprofen plasma concentrations and analgesic and antipyretic effects has been elucidated and a proposed site of action for nonsteroidal anti-inflammatory drugs is proposed. Expand
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The regulatory acceptance of achiral bioanalytical methods for ibuprofen bioequivalence studies is justified because the sum of both enantiomers is more discriminative than the chiral methods where only the eutomer is used for regulatory decisions. Expand
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Comparison of gastric endoscopic lesions and tolerability to ibuprofen and ibuprofen-arginate in healthy subjects.
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The aim was to compare gastric endoscopic lesions, in addition to tolerability, in healthy volunteers treated with ibuprofen or ib uprofen-arginate in humans, to demonstrate clinically significant differences. Expand
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