Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion

@article{Struve2007PreliminaryIO,
  title={Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion},
  author={Melanie F. Struve and Katie J. Turner and David C. Dorman},
  journal={Journal of Applied Toxicology},
  year={2007},
  volume={27}
}
In vitro, the organophosphate insecticide fenitrothion is a potent competitive androgen receptor antagonist, whereas in vivo it affects the development of the male rat reproductive system. The purpose of this pilot study was to determine whether prenatal exposure to fenitrothion affects development of the rat sexually dimorphic nucleus of the medial preoptic area (SDN‐POA). Pregnant rats (n = 5–6 litters/group) were orally dosed with corn oil (vehicle) or fenitrothion (20 or 25 mg kg−1 day−1… 

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