Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion

  title={Preliminary investigation of changes in the sexually dimorphic nucleus of the rat medial preoptic area following prenatal exposure to fenitrothion},
  author={Melanie F. Struve and Katie J. Turner and David C. Dorman},
  journal={Journal of Applied Toxicology},
In vitro, the organophosphate insecticide fenitrothion is a potent competitive androgen receptor antagonist, whereas in vivo it affects the development of the male rat reproductive system. The purpose of this pilot study was to determine whether prenatal exposure to fenitrothion affects development of the rat sexually dimorphic nucleus of the medial preoptic area (SDN‐POA). Pregnant rats (n = 5–6 litters/group) were orally dosed with corn oil (vehicle) or fenitrothion (20 or 25 mg kg−1 day−1… 

Quercetin Attenuates the Oxidative Injury–Mediated Upregulation of Apoptotic Gene Expression and Catecholaminergic Neurotransmitters of the Fetal Rats’ Brain Following Prenatal Exposure to Fenitrothion Insecticide

Evaluating the anti-apoptotic role of quercetin against the developmental neurotoxicity of fenitrothion revealed that the downregulation of apoptosis-related genes and catecholamines is an acceptable indicator for the neuroprotective efficiency of quERCetin especially during gestational exposure to organophosphate.

Reproductive Neuroendocrine Targets of Developmental Exposure to Endocrine Disruptors

The available experimental animal and epidemiological data are supportive of a potential role of EDCs on alterations of neuroendocrine development, and on pubertal onset, as well as the majority of the studies summarized herein focus on laboratory animals.

Effect of oral exposure to fenitrothion and 3-methyl-4-nitrophenol on splenic cell populations and histopathological alterations in spleen in Wistar rats

Findings indicate that FNT and MNP may selectively affect splenic T cells in rats, and apoptotic lymphocytes in spleen were observed in FNT-exposed rats under transmission electron microscope.

Selective effects of fenitrothion on murine splenic T-lymphocyte populations and cytokine/granzyme production

  • H. LiuJiang-xiong Li Mei-Yan Xu
  • Biology
    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
  • 2018
It is suggested that, due to oxidative damage, FNT selectively inhibits splenic T-lymphocyte survival and cytokine/granzyme production in vitro.

Walnut Polyphenol Extract Protects against Fenitrothion-Induced Immunotoxicity in Murine Splenic Lymphocytes

It is suggested that walnut polyphenol extract protects against FNT-mediated immunotoxicity and improves immune function by inhibiting oxidative stress.

Endocrine Disruptors and Puberty

Endocrine disruptors and puberty / , Endocrine disruptors and puberty / , کتابخانه دیجیتال جندی شاپور اهواز

Pesticide Exposure and Neurodevelopmental Outcomes: Review of the Epidemiologic and Animal Studies

Although the published animal studies may have characterized potential neurodevelopmental outcomes using endpoints not required by guideline studies, the effects were generally observed at or above effect levels measured in repeated-dose toxicology studies submitted to the U.S. Environmental Protection Agency (EPA).



Onset of the hormone-sensitive perinatal period for sexual differentiation of the sexually dimorphic nucleus of the preoptic area in female rats.

It is concluded that with the specific paradigm used in this study SDN-POA development is insensitive prior to day 18 of gestation, the day on which the onset of the hormone-sensitive period occurs.

Differential effects of the perinatal steroid environment on three sexually dimorphic parameters of the rat brain.

In males, the presence of the tests prenatally may be responsible for the initiation of masculinization of LH release mechanisms and the SDN-POA, but both require further androgen exposure for their completion.

Increased volume of the calbindin D28k-labeled sexually dimorphic hypothalamus in genistein and nonylphenol-treated male rats.

Both genistein and nonylphenol were found to increase the volume of the CALB-SDN in male rats (p's < 0.01), but not in female rats.

The Effect of Prenatal Exposure to the Phytoestrogen Genistein on Sexual Differentiation in Rats

The results confirm that prenatal exposure to estrogens in the environment can influence sexual differentiation and dosage and timing of exposure during development appear to be important factors in genistein's ability to modify these endpoints.

Prenatal exposure of testosterone prevents SDN-POA neurons of postnatal male rats from apoptosis through NMDA receptor.

It is suggested that testosterone, after being converted to estradiol, may prevent the SDN-POA neurons of male rats from apoptosis through enhancing the expression of NR(1) at the posttranscriptional level.

Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat.

  • K. TurnerN. Barlow P. Foster
  • Biology, Medicine
    Toxicological sciences : an official journal of the Society of Toxicology
  • 2002
Androgen-mediated development of the reproductive tract was altered in male offspring exposed in utero to maternally toxic levels of fenitrothion, as evidenced by reduction in anogenital distance on postnatal day (PND) 1 and retention of areolae on PND 13.

Evidence for the existence of a sexually dimorphic nucleus in the preoptic area of the rat

It is concluded that the marked sex difference in the volume of the SDN‐POA is due principally to an increase in the male of the total area of higher cell and neuronal density.