Preliminary in vivo efficacy studies of a recombinant rhesus anti-alpha(4)beta(7) monoclonal antibody.

@article{Pereira2009PreliminaryIV,
  title={Preliminary in vivo efficacy studies of a recombinant rhesus anti-alpha(4)beta(7) monoclonal antibody.},
  author={Lara E. Pereira and Nattawat Onlamoon and Xiaochun Wang and Rijian Wang and Jun-chang Li and Keith A Reimann and Francois Villinger and Kovit Pattanapanyasat and Kenta Mori and Aftab A Ansari},
  journal={Cellular immunology},
  year={2009},
  volume={259 2},
  pages={165-76}
}
Recent findings established that primary targets of HIV/SIV are lymphoid cells within the gastrointestinal (GI) tract. Focus has therefore shifted to T-cells expressing alpha(4)beta(7) integrin which facilitates trafficking to the GI tract via binding to MAdCAM-1. Approaches to better understand the role of alpha(4)beta(7)+ T-cells in HIV/SIV pathogenesis include their depletion or blockade of their synthesis, binding and/or homing capabilities in vivo. Such studies can ideally be conducted in… CONTINUE READING

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