Understanding how odorants mediate the migratory behaviors of sea lamprey has become a central research focus for the Great Lakes Fishery Commission in their quest to find new alternative control measures for this devastating invasive species. One particularly novel tactic developed for use in managing agricultural pests, the Push-Pull Approach, involves the use of behavior-modifying chemical stimuli to manipulate the destination of lampreys as they migrate into rivers to spawn. The approach relies on the simultaneous use of attractants and repellents to guide lampreys away from high quality larval rearing habitat and into target areas where larval survival, and subsequent recruitment to the parasitic stage, is minimized. The attractant has been chemically identified (larval/migratory pheromone), synthesized, and is currently undergoing largescale testing. The repellent awaits discovery.