Preliminary evidence of reduced combined output of dopamine and its metabolites in chronic schizophrenia.

@article{Karoum1987PreliminaryEO,
  title={Preliminary evidence of reduced combined output of dopamine and its metabolites in chronic schizophrenia.},
  author={Farouk Karoum and Craig N Karson and Llewelyn B Bigelow and William Lawson and Richard Jed Wyatt},
  journal={Archives of general psychiatry},
  year={1987},
  volume={44 7},
  pages={604-7}
}
The mean combined total body excretion of dopamine (DA) and its metabolites, measured by summing the molar excretion of DA and its metabolites in 24-hour urine samples (Sum DA), was reduced in 20 patients with schizophrenia who had not been receiving medication for at least two weeks. These patients were relatively resistant to treatment, as they were unable to live independently outside institutional settings despite conventional neuroleptic therapy. In contrast, sum norepinephrine (Sum NE… CONTINUE READING