Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects

@article{Krystal2004PreliminaryEO,
  title={Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects},
  author={John H. Krystal and Walid Michel Abi-Saab and Edward Perry and Deepak Cyril D’Souza and Nianjin Liu and Ralitza Gueorguieva and Lisa M. McDougall and Tracy Hunsberger and Aysenil Belger and Louise R. Levine and Alan Breier},
  journal={Psychopharmacology},
  year={2004},
  volume={179},
  pages={303-309}
}
Some of the behavioral consequences of deficits in N-methyl-d-aspartate (NMDA) glutamate receptor function are thought to arise from the disinhibition of cortical glutamatergic circuitry. This study evaluated whether pretreatment with a drug that reduces glutamatergic activation, the group II metabotropic glutamate receptor (mGluR) agonist, LY354740, reduced the cognitive effects of the NMDA glutamate receptor antagonist, ketamine, in healthy human subjects. Nineteen healthy human subjects… CONTINUE READING
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