Preliminary evidence for methamphetamine-induced behavioral and ocular effects in rat offspring following exposure during early organogenesis

@article{AcuffSmith1992PreliminaryEF,
  title={Preliminary evidence for methamphetamine-induced behavioral and ocular effects in rat offspring following exposure during early organogenesis},
  author={Karen D. Acuff-Smith and Magdalena M. George and Stanley A. Lorens and Charles V Vorhees},
  journal={Psychopharmacology},
  year={1992},
  volume={109},
  pages={255-263}
}
Gravid Sprague-Dawley CD (VAF) rats received 50 mg/kg (d,l)-methamphetamine (MA) HCl (expressed as free base,N=15) or distilled water (N=6) by SC injection × 2/day in a 3 ml/kg volume on embryonic (E) days 7–12. Control rats were pair-fed to MA-exposed dams on days E7–18. No control dams failed to deliver; however, of 15 MA-exposed dams 4 did not deliver (2 died and 2 had completely resorbed litters). One additional MA litter had all the offspring die shortly after birth. There was no… CONTINUE READING
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