Preliminary evidence for an association between intake of high‐fat high‐sugar diet, variations in peripheral dopamine precursor availability and dopamine‐dependent cognition in humans

  title={Preliminary evidence for an association between intake of high‐fat high‐sugar diet, variations in peripheral dopamine precursor availability and dopamine‐dependent cognition in humans},
  author={Hendrik Hartmann and Larissa K Pauli and Lieneke K. Janssen and Sebastian Huhn and Uta Ceglarek and Annette Horstmann},
  journal={Journal of Neuroendocrinology},
Obesity is associated with alterations in dopaminergic transmission and cognitive function. Rodent studies suggest that diets rich in saturated fat and refined sugars (HFS), as opposed to diets diets low in saturated fat and refined sugars (LFS), change the dopamine system independent of excessive body weight. However, the impact of HFS on the human brain has not been investigated. Here, we compared the effect of dietary dopamine depletion on dopamine‐dependent cognitive task performance… 
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Results suggest that intake of saturated lipids can suppress DA signaling apart from increases in body weight and adiposity-related signals known to affect mesolimbic DA function, in part by diminishing D1 receptor signaling, and that equivalent intake of monounsaturated dietary fat protects against such changes.
Reduced phasic dopamine release and slowed dopamine uptake occur in the nucleus accumbens after a diet high in saturated but not unsaturated fat
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