Preliminary evaluation of the human relevance of respiratory tumors observed in rodents exposed to naphthalene.

@article{Piccirillo2012PreliminaryEO,
  title={Preliminary evaluation of the human relevance of respiratory tumors observed in rodents exposed to naphthalene.},
  author={Vincent J Piccirillo and Michael G. Bird and Robert J. Lewis and W James Bover},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2012},
  volume={62 3},
  pages={433-40}
}
Inhalation bioassays in mice and rats exposed to naphthalene (NA) show incidences of lung and nasal cancer, respectively. This paper describes a preliminary mode of action (MOA)/human relevance (HR) framework for NA. Species differences in both carcinogenic and cytotoxic responses between the rodent and human have been noted based on qualitative and quantitative differences in metabolism. Some occur at the initial oxidation of NA in the rat through CYP2F, versus CYP2A13 metabolism in the human… CONTINUE READING