Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain fatty acids.

@article{Gmez2002PreliminaryEO,
  title={Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain fatty acids.},
  author={Rafael G{\'a}mez and Idania Rodeiro and I. Redondo Fern{\'a}ndez and Pilar Caridad Acosta},
  journal={Teratogenesis, carcinogenesis, and mutagenesis},
  year={2002},
  volume={22 3},
  pages={175-81}
}
D-003 is a mixture of very long chain aliphatic acids purified from sugar cane wax, wherein octacosanoic acid represents the major component. Previous experimental studies have shown that D-003 inhibits platelet aggregation in rodents. Also, its lowers total (TC) and low-density lipoprotein cholesterol (LDL-C) in normocholesterolemic rabbits in a dose-dependent manner and inhibits cholesterol biosynthesis in fibroblast cultures. The present study was performed to investigate the in vitro… CONTINUE READING