Preliminary evaluation of pharmacological properties of some xanthone derivatives.

@article{Marona2009PreliminaryEO,
  title={Preliminary evaluation of pharmacological properties of some xanthone derivatives.},
  author={Henryk Marona and Natalia Szkaradek and Anna Rapacz and Barbara Filipek and Małgorzata Dybała and Agata Siwek and Marek T. Cegła and Edward Szneler},
  journal={Bioorganic \& medicinal chemistry},
  year={2009},
  volume={17 3},
  pages={
          1345-52
        }
}
A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for alpha(1)- and beta(1)-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly… Expand

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