Preliminary data on the age-dependent decrease in basic fibroblast growth factor and platelet-derived growth factor in the human vein wall and in their influence on cell proliferation.

@article{Drubaix1998PreliminaryDO,
  title={Preliminary data on the age-dependent decrease in basic fibroblast growth factor and platelet-derived growth factor in the human vein wall and in their influence on cell proliferation.},
  author={I. Drubaix and A Giakoumakis and Ladislas Robert and A. M. Robert},
  journal={Gerontology},
  year={1998},
  volume={44 1},
  pages={9-14}
}
The roles of basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) in vein disease and aging were investigated. Smooth muscle cells from human saphenous veins were cultured. The age dependence of bFGF and PDGF activation of the smooth muscle cell proliferation was determined, and the bFGF and PDGF contents in vein wall homogenates were measured by an enzyme-linked sorbent assay. There were morphological alterations in the cells with more polygonal and polynucleated… CONTINUE READING

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